In view of the problem of premature convergence and stagnation in the Differential Evolution (DE), the distributed memetic differential evolution was put forward. The idea of memetic algorithm was introduced into the DE algorithm. The distributed population structure and the combination strategy in memetic algorithm were applied. In the former strategy, the initial population was divided into multiple subpopulations according to the von Neumann topology and the periodical information exchange was realized among the subpopulations. And in the latter idea, the differential evolution was taken as an evolutionary frame that was assisted by pattern search to balance the exploration and exploitation abilities. The proposed algorithm made full use of advantages of the pattern search and differential evolution, set up an effective search mechanism and enhanced the algorithm to break away from local optima so as to satisfy the demand on population diversity and convergence speed of the search process. The proposed algorithm was run on a set of classic benchmark functions and compared with several state-of-the-art DE algorithms. Numerical results show that the proposed algorithm has excellent performance in terms of solution quality and convergence speed for all test problems given in this study.